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DIABETES
FDA revises recommendation
for metformin use in
patients with chronic
kidney disease
3
Hypoglycaemia remains
a most challenging
obstacle
6
OBESITY
Overweight, obesity leads to
higher mortality
8
METABOLIC
& ENDOCRINE
DISORDERS
My approach to the
patient with memory
loss who needs
a statin
10
CARDIOVASCULAR
COMPLICATIONS
Encourage intake of whole,
not refined, grains
13
CHRONIC KIDNEY
DISEASE
Exercise caution in
certain patients
14
OPINION
...no matter how
compelling,
observational data
and biological
plausibility do
not necessarily
predict the ability
of a therapeutic
manipulation of a
biomarker to alter
clinical outcomes.
Dr Peter Libby
15
One of the biggest
conversation points in
diabetes these days is
around the impact of the
newer diabetes drugs on
cardiovascular mortality,
the role of epigenetics in
diabetes, and the potential
impact of an artificial
pancreas system on patients
with type 1 diabetes.
Diabetes
landscape
in Australia is
fast evolving
Life-years lost to diabetes
Diabetes Research and
Clinical Practice
Life-years lost to diabetes decreased
as age at diabetes diagnosis increased;
those diagnosed before 20 years
of age lost 20 years whereas those
diagnosed after 80 years of age lost
no years.
4
Prevalence of diabetic
retinopathy in newly diagnosed
type 2 diabetes
Diabetologia
Based on fundus photographs,
researchers observed that 13% of
participants with newly diagnosed
type 2 diabetes had DR.
5
BMI and mortality risk
The Lancet
Mortality risk increased log-linearly
with BMI for BMI >25 kg/m
2
;
the hazard ratio per 5 kg/m2 higher
BMI was1.29 to 1.39, depending
on the continent.
8
LDL levels and major adverse
cardiac events in ischaemic heart
disease treated with statins
JAMA Internal Medicine
In patients with ischaemic heart
disease who are compliant with statin
therapy, LDL levels ≤100 mg/dL are
associated with reduced risk
of MACE.
11
ISSN 2206-4656
VOL. 1 • No. 2 • 2016
RESEARCH NEWS AND VIEWS FROM ELSEVIER
FORMERLY CLINICAL ENDOCRINOLOGY NEWS