2016 Top Stories
in Oncology
Interventions for preventing
cardiomyopathy due to anthracyclines:
a Bayesian Network meta-analysis
Annals of Oncology
This systematic review and meta-analysis
found that dexrazoxane (based on moderate-
quality data) and angiotensin antagonists (based
on low-quality data) are potentially effective
in preventing cardiotoxicity associated with
anthracycline treatment.
5
Vitamin D receptor genotype,
vitamin D3 supplementation,
and risk of colorectal adenomas:
a randomized clinical trial
JAMA Oncology
For the prevention of advanced colorectal
adenomas, the benefits of vitamin D3
supplementation may vary based on
the vitamin D receptor genotype.
6
Adjuvant sunitinib in
high-risk renal-cell carcinoma
after nephrectomy
New England Journal of Medicine
The study results showed that sunitinib
significantly lengthened disease-free survival
in patients with locoregional clear cell RCC
at high risk for tumour recurrence following
nephrectomy, although this benefit was
accompanied by increased adverse events.
9
EDITOR’S PICKS
Atezolizumab for advanced
urothelial carcinoma,
adjuvant sunitinib for high-
risk RCC after nephrectomy
and 10-year outcomes for
localised prostate cancer
8
ASH 2016
10
Complete remissions with
anti-CD22 CAR-T in children with
relapsed/refractory ALL
Patients who reached
target second-maintenance-
dose antithrombin III level
achieved complete response
of veno-occlusive disease
SABCS 2016
22
Serial evaluation of plasma
circulating tumour DNA can
detect molecular response
to treatment for metastatic
breast cancer
PIK3CA mutation testing from
ctDNA may potentially be used
as a surrogate for unknown or
wild-type mutation status when
tissue is unavailable
VOL. 2 • NO. 1 • 2017
RESEARCH NEWS AND VIEWS FROM ELSEVIER
ISSN 2206-463X