Unexpectedly, in the SUSTAIN-6 study, a small
safety study of the once-weekly GLP1 analog
semaglutide, semaglutide significantly reduced
the risk of cardiovascular death, MI, or stroke by
26% compared with placebo in 3297 patients
with diabetes and at high cardiovascular risk.
11
SUSTAIN-6:
results
encouraging for
the entire field of
cardiometabolic
drug development
Increased mortality in people
with impaired glucose
tolerance after the onset
of diabetes
Diabetes Care
This study demonstrates that
a large portion of the increased
mortality risk in patients with
impaired glucose tolerance is
attributable to development of
type 2 diabetes.
10
Optimized mealtime insulin dosing
for fat and protein in type 1 diabetes:
application of a model-based
approach to derive insulin doses for
open-loop diabetes management
Diabetes Care
Regardless of carbohydrate content,
the fat and protein content of
meals appears to increase insulin
requirements in patients with
type 1 diabetes.
11
Magnitude of weight loss and
changes in physical fitness linked
with long-term cardiovascular
disease outcomes in overweight
diabetics
The Lancet Diabetes & Endocrinology
In this secondary analysis of the Look
AHEAD trial, investigators found that
greater weight loss and greater change
in fitness level was associated with
reduced cardiovascular disease.
12
Metformin beneficial
for overweight due to
antipsychotics in children
with autism
JAMA Psychiatry
In children and adolescents
with ASD and weight gain due
to antipsychotics, metformin
may be effective for weight
reduction.
14
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PracticeUpdate
Endocrinology
Readers Poll.
OPINION
The analysis
demonstrated the
difficulty of
maintaining
haemoglobin A1c
to goal over 3 years,
even in a clinical
trial setting.
6
CONFERENCE
EASD 2016
Pregnancy outcomes of
women with gestational
diabetes are worse but most
differences are due to higher
body weight
5
Even in a clinical trial setting,
keeping HbA1c at goal for
3 years is difficult
6
Platelets from poorly
controlled type 2 diabetes
patients show impaired
ability to protect against
cardiac ischaemia/
reperfusion injury
9
DIABETES
Insulin infusion and glucose
monitoring: a guideline for
diabetes technologies
10
OBESITY
Double diabetes does
not have to mean double
complications
13
FEATURE ARTICLE
Improved glycaemic
control with closed-loop
insulin in pregnant
diabetic women
15
ISSN 2206-4656
VOL. 1 • No. 3 • 2016
RESEARCH NEWS AND VIEWS FROM ELSEVIER
FORMERLY CLINICAL ENDOCRINOLOGY NEWS