C h a p t e r 1 5
Innate and Adaptive Immunity
343
C.
Is this an example of active or passive
immunity? Is it a primary or secondary immune
response?
3.
A 5-month-old child presents with thrush, a yeast
infection of the mouth. In the last 2 months, he
has had recurrent bouts of otitis media. His tonsils
are very small. Laboratory analysis indicates a
low lymphocyte count and no T lymphocytes.
Further analysis indicates a genetic mutation in
the T-cell receptor that affects maturation of all
T cells. The final diagnosis is severe combined
immunodeficiency disease. A bone marrow
transplant is being pursued with cells from his
HLA-matched sibling.
A.
Explain why infections were not present in the
first few months of this child’s life.
B.
What would be the impact of an absence of
T cells on both humoral and cell-mediated
immunity?
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