Advanced Physics for Brachytherapy 2018

Difference between models and simulated (TCP and NTCP) dose-response

dose

systematic

random

(Gy EQD2

)

U

5% U r

10% U r

20%

a/b = 10Gy

s

75

1.0% -0.1% -0.3%

D TCP

90

0.8% -0.1% -0.3%

(Gy EQD2

)

U

5% U r

10% U r

20% U r

30%

a/b = 3Gy

s

65

0.5%

0.1% 1.1% 2.3%

D NTCP

75

1.4%

0.2% 1.6% 3.2%

“Can reduction of uncertainties in cervix cancer brachytherapy potentially improve clinical outcome?” Nesvacil et al. 2016, submitted to R&O