Advanced Physics for Brachytherapy 2018

Conclusions

• Extreme hypo with BT bears large dosimetric uncertainties, and benefits from high target dose per fraction: flat part of dose response curve is less sensitive to uncertainties in dose

• Future development of BT fractionation schemes should take into account

➢ Existing/missing knowledge about dose response relationships ▪ For target and OARs!

➢ Existing/missing knowledge about uncertainty budget of the specific treatment technique and workflow

➢ All these combined will help to improve safety of predicting the optimal therapeutic window