207_Combined course Presentations

Oncogene Addiction: 2 models

a) genetic streamlining theory

The ‘genetic streamlining’ theory postulates that non-essential pathways (top, light grey) are inactivated during tumour evolution, so that dominant, addictive pathways (red) are not surrogated by compensatory signals. Upon abrogation of dominant signals, there is a collapse in cellular fitness and cells experience cell-cycle arrest or apoptosis (bottom, red to yellow shading).

Torti and Trusolino, 2011