207_Combined course Presentations

Umbrella trials matching patients to therapies based on molecular profiles

Primary outcome measure(s)

Lead organization

# Expected to accrue

Clinicaltrials.gov identifier

Program name

Design

Histology

Indication

Advanced non- V600–mutated

GEMM

Yale University R

Metastatic

96

BORR

NCT02094872

metastatic melanoma

Quantum Leap Healthcare Collaborative

Locally advanced breast cancer

ISPY-2

A–R

Neo-Adjuvant 800

pCR

NCT01042379

10,000 (screening)

LUNG-MAP

SWOG and NCTN R

Squamous

Metastatic

PFS

NCT02154490

Metastatic non- HER2 + breast cancer

400 (screening) 210 (randomized)

SAFIR-02 breast UNICANCER R

Metastatic

PFS

NCT02299999

650 (screening) + 220 (treatment)

SAFIR-02 lung UNICANCER R

NSCLC

Metastatic

PFS

NCT02117167