207_Combined course Presentations

Impact of IMRT compared to 3D-CRT: Heart dose

Overall survival univariate analysis

Co-variate

HR

95% CI

P-value

Heart Doses

Heart V20 1.008 1.004, 1.013 0.0005

Heart V40

1.013

1.006, 1.021 0.0005

Heart Doses

3D-CRT IMRT P-value

Heart V60

1.023 1.007, 1.039 0.0051

V20

23.5% 19.3% 0.049

V40

11.4% 6.8% 0.003

Overall survival multivariate analysis

V60

2.4% 1.4% 0.045

Co-variate

HR 95% CI

P-value

Heart V40 1.013

1.005, 1.02 0.0008

 CONCLUSION : in RTOG 0617 trial, IMRT was associated with lower rates of severe pneumonitis and cardiac doses , which supports routine use of IMRT for locally advanced NSCLC

Chun SG. et al. JCO 2017;35