207_Combined course Presentations

Meta-analysis of PCI in SCLC : RT doses

Relative risk of death (95% CI)

Relative risk of brain mets (95% CI)

Total dose

p value

p value

8 Gy

0.69 (0.35-1.37)

0.76 (0.28-2.10)

24-25 Gy

0.88 (0.75-1.04)

0.52 (0.41-0.67)

0.02

NS

30 Gy

0.81 (0.59-1.12)

0.34 (0.19-0.59)

36-40 Gy

0.81 (o.54-1.20)

0.27 (0.14-0.51)

Timing (between start of induction CT and randomization to PCI)

< 4 mo

0.92 (0.66-1.29)

0.27 (0.16-0.46)

4-6 mo

0.79 (0.61-1.02)

0.50 (0.35-0.72)

0.01

NS

> 6 mo

1.01 (0.74-1.38)

0.69 (0.44-1.08)

Auperin A. et al. NEJM 1999;341