207_Combined course Presentations

Japanese trial: futility of PCI when mets are excluded by MRI

OS @ 12 months: 11.6% vs 13.7%

Brain mets @ 12 months: 58% vs 32.4%

 Study early terminated because of futility after 1 st interim analysis

 PCI did not result in longer OS compared with observation in patients with any response to initial chemotherapy and a confirmed absence of brain metastases when patients receive periodic MRI examination during follow-up.

Takahashi T. et al. Lancet Oncol 2017