207_Combined course Presentations

Integrate pathology and biology

Histologic Grade

Low ( I of III)

Intermediate (II of III)

High (III of III)

Biomarkers

ER expression

+++

++ to +++

+ to ++

PR expression

++ to +++

0 to +++

0 to ++

Proliferation (Ki-67 / S phase fraction)

Low (<10%)

Intermediate (10-20%)

High (>20%)

HER2 Overexpression

Never

Occasional

Occasional

Genetic / Genomic / multipanel markers

21-gene recurrence score

Low (< 18)

Intermediate (18-25)

High ( >25)

Intrinsic subtype

Luminal A

Luminal B

Genomic Grade

Lower

Higher

IHC4

Lower

Higher risk

MammaPrint

Low

High

Tumor DNA ploidy

Mostly diploid

Mostly aneuploid

St Gallen 2017

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