207_Combined course Presentations

Adjuvant therapy

Relative Indications for chemotherapy in addition to endocrine therapy

Area of uncertainty for indication to chemotherapy in addition to endocrine therapy

Relative Indications for endocrine therapy alone

Histological Grade 3 High or intermediate “genomic risk”

Histological Grade 2 Intermediate “genomic risk”

Histological Grade 1 Low “genomic risk”

High proliferation a

Intermediate proliferation

Low proliferation

High/Intermediate degree of ER and PgR expression

Lower ER and PgR level

Higher ER and PgR level

Node positive (4 or more involved nodes) Presence of extensive peritumoral vascular invasion

Node positive (1-3 involved nodes)

Node negative

Absence of extensive peritumoral vascular invasion

pT > 5 cm

pT 2.1 – 5 cm

pT ≤ 2cm