207_Combined course Presentations

Kinases in Oncology

 Kinases are involved in processes leading to cell proliferation and survival

 Kinases are popular targets - virtually every signal transduction process is wired through phosphotransfer cascade - despite high degree of conservation highly specific agents can be developed - inhibition of kinase in normal tissue can often be tolerated (therapeutic window) - to date approx. 80 inhibitors advanced to some stage of clincial evaluation