207_Combined course Presentations

Triple negative: a spectrum

Subtype

Gene expression profile

Clinical

Basal-like 1 Basal-like 2

high Ki-67; DNA damage response BRCA-associated

GF pathways Immune genes

Higher pCR

Immunomodulatory

Mesenchymal

Cell motility

Lower DDFS

Mesenchymal stem-like

Cell motility; claudin-low

Luminal androgen receptor Steroid pathways

Apocrine features, higher LRF; PI3Kmut

38

Lehman BD, et al. J Clin Invest 2011;121:2750-67.