207_Combined course Presentations

CAO/ARO/AIO-04 Trial

Primary Endpoint DFS Median Follow-up: 50 months (range: 0.3-73) Time between randomisation and the first of the following events: Incomplete local resection (R2) Locoregional recurrence after R0/R1 resection (+/- distant metastases)

5-FU arm n=623

5FU/OX arm n=613

10

5

23 (3.7%)

12 (2%)

Distant metastases / Progression

149

115

Death

Overall Cancer / treatment related/surgical mortality

106 69/4/6 26 1

96 54/7/4 31 0

Unrelated Unknown

First events for DFS (total)

198

159

Ref: Adapted from Rodel et al, ASCO 2014