207_Combined course Presentations
CD137: CD137L
Function:
On T cells increasing: proliferation, resistance to apoptosis, IFNγ secretion increase in tumor-selective cytolytic T-cell activity
On DC Enhancing co-stimulation
On T reg: Reduction of T regs infiltration
On NK Enhanced ADCC (antibody-dependent cell- mediated cytotoxicity)
Clin Cancer Research July 2015 Volume 21, Issue 14
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