207_Combined course Presentations

Toxicity of concurrent SRT and tyrosine kinase inhibitors (TKIs)

Multi receptor TKIs (sorafenib, sunitinib)

 Cranial SRT + sorafenib or sunitinib: safe but one grade 5 toxicity has been observed for sunitinib.

 For extra-cranial SRT, liver SRT combined with sorafenib is associated with severe toxicity

 No radiation induced toxicity sunitinib and extra-cranial SRT.

Kroeze S et al. Cancer Treatment Reviews 53 (2017) 25–37