207_Combined course Presentations

Activation of signaling cascade

dimerization

ligand binding

ligand binding

extracellular ligand binding domain

transmembrane domain

P

P

Tyr

Tyr

Tyr Tyr

Tyr Tyr

P

P

Tyr

Tyr

intracellular tyrosine kinase domain

P

P

Tyr

Tyr

Tyr

Tyr

P

P

Tyr

Tyr

Tyr

Tyr

Tyr

Tyr

P

P

Tyr

Tyr

activation of signaling cascades