207_Combined course Presentations

DIFFERENT BINDING SITES – DIFFERENT MECHANISMS

EXTRACELLULAR DOMAIN OF PROTEIN AS TARGET STRUCTURES!

Cetuximab (C225)

Trastuzumab

Pertuzumab

Competition to EGF-binding Inhibition of Dimerization

Stimulation of endocytosis

No heterodimerization

Multiple downstream mechanisms leading to e.g. radiosensitization