207_Combined course Presentations

Secondary and Downstream Mutations

Kobayashi, PLoS Med, 2, e73

Sensitivity to Gefitinib Differs Among NSCLC Cell Lines Containing Various Mutations in EGFR or KRAS The three indicated NSCLC cell lines, H3255 (L858R mutation), H1975 (both T790M and L858R mutations), and H2030 (wild-type EGFR, mutant KRAS ), were grown in increasing concentrations of gefitinib, and the density of live cells after 48 h of treatment was measured