207_Combined course Presentations

Key Points

Molecularly targeted agents are less toxic than cytotoxic agents (antibodies/small molecular resistances Molecularly targeted agents work by targeting the genetic

changes(s) in cancer cells Chromosomal translocation Gene duplication Gene mutation Risk for secondary mutations high

Risk for paraxodical activation of pro-tumorigenic wildtype-signal transduction cascade exists (Raf- inhibitors) To improve cancer treatment, we need to better understand the differences between cancer and normal cells