207_Combined course Presentations

“Window of Opportunity” Trials

Reprogramming? Resistance?

Newly diagnosed pt Tumor in place

Drug Rx

Short duration Not intended for therapy

• Good for:

• Bad for:

– Discovery – Proof of principle (e.g. Johnson presentation)

– Unknown agents – ? Testing combinatorial strategies • Doses? • Toxicity issues

These contribute to scientific knowledge and therapeutic hypotheses, not clinical care