207_Combined course Presentations

Residual Disease Trials

Post-Rx residual disease

New Diagnosis

Relapse

Neoadjuvant Rx

Investigational Drug Rx

• Bad  :

• Good  :

– Adjuvant-size trial – Cannot assess response (event = relapse)

– Tissue available – Resistant tumors – High risk population

Example: PENELOPE – palbociclib in residual ER+ disease