207_Combined course Presentations

ADXS11-001 immunotherapy

• live attenuated Listeria monocytogenes (Lm) • bioengineered to secrete a HPV-16-E7 fusion protein targeting HPV transformed cells.

• Anal cancer cells infected with HPV have the tumour associated antigen HPV E7.

• So ADXS11-001 causes antigen presenting cells to be stimulated to facilitate immune cells to attach to cancer cells expressing HPV E7