207_Combined course Presentations

PLATO – PERSONALISING RADIOTHERAPY DOSE FOR ANAL CANCER

T1,T2<4cm N0

T1 N0 Anal margin

T3/4 NO T2N2, T3/4 N1-3

Standard

ACT4

ACT3

Local excision

53.2Gy 28F

58.8Gy 28F

61.6Gy 28F

Adverse

Pilot

50.4Gy 28F

41.4Gy 23F

Obs

41.4Gy 23F

Ph II

Stratify for Cape vs. 5-FU

Courtesy of David Sebag-Montefiore

Ph III

Phase II trial

Phase II/III trial