207_Combined course Presentations

LGG: classical prognostic factors

Pignatti F. et al. JCO 2002;20

Gorlia T. et al. Neuro-Oncol 2013;15

Prognostic factors for OS: multivariate model

Prognostic factors for OS: multivariate model

Variable

HR p value

Variable

HR p value

 Age

≥40 vs <40 y

1.26

0.0077

 Pre-surgical

 Neurologic deficit

Worse baseline

1.5

<0.0001

Yes vs No

1.35

0.0013

neurologic status

Neurologic deficit

 Largest diameter

 Largest diameter

<5 cm vs ≥5 cm

1.7

<0.0001

≥6 cm vs <6 cm 1.39

0.0003

 Histology subtype

 Histology subtype

Astro vs Oligo

1.9

<0.0001

Astro vs Oligo

1.30

0.0050

 Tumor crossing

 Shorter time since

>30 weeks vs

0.67

0.009

Yes vs No

1.37

0.0005

the midline

first symptoms

<30 weeks

(only EORTC)