207_Combined course Presentations

RT+CT in HR LGG: RTOG 98-02

 251 patients randomly assigned to receive 54 Gy RT alone (126) or 54 Gy RT + adjuvant PCV x 6 (125)  High risk patients according to RTOG criteria: • Age<40, with partial resection or biopsy • Age>40

Median PFS: 10.4 vs 4 years p < 0.0001

Median PFS: 13.3 vs 7.8 years p = 0.002

Buckner JC et al. NEJM 2016;374