207_Combined course Presentations

RT vs TMZ in HR LGG: EORTC 22033 (molecular analysis)

IDHmut/1 p • Median PFS: 

19

intact

q

RT 55.4 months TMZ 36 months

p = 0.0043



CONCLUSION

Our results might support the option

of

initial TMZ alone

in good-

IDHmut/1 p • Median PFS: 

19

codel

q

prognosis tumors (IDHmut/1 p 19 q codel), in order to minimize the

RT 61.6 months TMZ 55 months

p = n.s.



potential risk of late toxicity by

postponing RT (if TMZ could be used

instead) in a patient population who

IDHwt • Median PFS:

might live for more than 10–20 years.



RT 19.1 months

p = n.s.



TMZ 23.7 months