207_Combined course Presentations

Stupp Regimen: EORTC/NCIC trial – beneficial role of TMZ

Protocol schema

Concurrent TMZ/RT

Adjuvant TMZ

• Median OS: 14.6 vs 12.1 months p < 0.001

R

0

6

10 14 18 22 26 30

Weeks

RT Alone

Temozolomide 75 mg/m 2 po qd for 6 weeks, then 150–200 mg/m 2 po qd d1–5 every 28 days for 6 cycles Focal RT daily — 30 x 2 Gy Total dose 60 Gy

Stupp R. et al. NEJM 2005;352