207_Combined course Presentations

Relevance of Immune System for Treatment Response

800

control

PTK RT

700

combined

600

500

400

300

200

100

tumor volume mm3 Treatment

Tumor in immune compromised mice

0

0

10

20

30

40

50

0 100 200 300 400 500 600 700 800

control

RT

combined

PTK

tumor volume mm3 Treatment

Tumor in immune-competent mice

0

10

20

30

40

50

days after treatment start

Minimal Treatment Schedule: 4 x 3 Gy + 4 x 100 mg/kg PTK787

Riesterer et al., 2007, 2011