207_Combined course Presentations

Enrichment and patient selection

Element

Challenges

Solutions

Molecular selection

Central screening •

Activate molecular screening programs national based or locally supported using validated multiplexed assays (funding remain an issue)

Archived tumor samples requested

Return of molecular information

•

Turnaround time variable

•

Local screening •

Local screening not reimbursed

Assay may not be validated in CLIA lab

•

Identification of rare subset of patients

Screening costs while number of eligible patients with financial challenges to keep many trial open with less patients recruited

Support for screening Multiplexed screening Umbrella or basket protocols