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XRT in skin cancers – contraindications

Xerodermia pigmentosa Gorlin syndrome – induction of new skin cancers

Verrucous carcinoma – anaplastic transformation, metastases Site of previous XRT – late damages to normal tissues, cumulative effect of XRT Bone / cartilage invasion Relative: Multifocal tumours with areas of dysplastic skin Young patients (below 40-50 yrs, late complication, carcinogenesis) Hair bearing area Inner canthus Upper (outer) eyelid Lesions over bones or cartilages (painful chondro– or osteonecrosis, disfigurement)