Physics Bucharest 2017

EMbrace clinical trial • European study on MRI-guided brachytherapy in locally advanced cervical cancer

• Multi-centre observational study to introduce MRI based 3D brachytherapy planning in 27 centres

• Collect data on outcomes and develop prognostic / predictive markers with > 1200 patients recruited end 2014

• EMBRACE II opening with many more centres aiming to participate

• ICRU 89: New recommendations for gynaecological brachytherapy published 2016

• Higher dose to HR CTV improves control >85Gy • Need to use interstitial needles in larger tumours • Lower doses in smaller tumours