Physics Bucharest 2017

Prostate Cancer Level I (RCT) evidence: EBRT +/- BT boost

Hoskin 2007 (UK)

Morris 2015 (Canada)

No. patients

218

398

Mean age yrs

68.9

68

Technique

HDR (8.5Gyx2)

LDR (115Gy)

Risk groups

Low 4% Inter 42% High 54%

Inter 31% High 69%

Outcomes

At 7.1 yrs 31% reduction in recurrence

50% reduction in PSA recurrence ↑ late GU toxicity EBRT comparator 76Gy but not IMRT/IGRT

Criticism

EBRT comparator only 55Gy/20