Physics Bucharest 2017

Energy deposition Excitation/ionization Initial particle tracks

10-15

PHYSICAL INTERACTIONS

10-12

Radical formation

10-9

PHYSICO-CHEMICAL INTERACTIONS

Diffusion, chemical reactions Initial DNA damage

10-6

DNA breaks / base damage

1 ms

10-3

Timing of events

TIME (sec)

1 second

Repair processes

100

Damage fixation

BIOLOGICAL RESPONSE

103

1 hour 1 day

Cell killing

Proliferation of "damaged" cells Mutations/transformations/aberrations

106

Promotion/completion

1 year

Teratogenesis Cancer

MEDICAL EFFECTS

109

100 years

Hereditary defects