Physics Bucharest 2017

Clinical data

Life Span Study

 adverse effects of radiation in atomic bomb survivors (Hiroshima, Nagasaki)  ~ 90.000 survivors  irradiated with mainly photons and small portion of neutrons  Mean whole body dose = 0.2 Sv  97.6% had whole body dose < 1 Sv  ~ 36.000 persons had dose < 0.005 Sv (internal reference, negligible dose)

Between 0.05 Sv and 2 Sv (single dose): linear dose response relationship for induction of solid tumors Clinical data

100 mSv whole body to US population: • EAR ≈ 1%  1% of population will get radiation-induced tumor • ERR ≈ 2.5%  total number of tumors increases by 2.5%

*BEIR VII, phase II, DDREF=1.5

17