Physics Bucharest 2017

Position of RT induced 2 nd tumors relative to HIGH DOSE AREA

 4581 cases of childhood cancer  115 children with second tumor after RT  mean age at diagnosis 5 years

 12 % in PTV  66% around beam edge  22% > 5 cm from beam edge

 70 % D>2.5 Gy  20 % D<0.5 Gy

Clinical data

Majority of secondary solid cancers close to, or in PTV

beam edge

Diallo et al, IJROBP 2009

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