Physics Bucharest 2017

Controversies  The LQ model. Still valid for big fraction sizes? Most data are for fraction sizes 1-5 Gy. Controversial if alternative models required at higher fraction sizes.  At big fraction sizes the lack of re-oxygenation would predict worse outcomes than we see.  Perhaps endothelial damage (apoptosis) important?  Vascular damage causes secondary tumour cell killing?  Immune effect?  How significant is tumour hypoxia – especially for single fraction treatment.