Physics Bucharest 2017

Clinical use of IMRT: What’s the evidence?

Improved dose distribution → clinical benefit?

 Review 2012 on IMRT vs. non-IMRT :

3 RCT in LA-H&N (205 pts),

Evidence

 61 comparative studies; only 6 RCT

3 RCT in breast cancer (1809 pts)

 Primary endpoints: acute and late toxicity  Not powered to detect differences in tumor control

Staffurth Clin Oncol 2010 De Neve Semin Radiat Oncol 2012

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