Physics Bucharest 2017

Head & Neck cancer

Scientific evidence: 4 RCT

Study

Organ

IMRT/ non-MRT

Primary endpoint Other endpoints Xerostomia ≥2 (2y) Acute fatigue 2y OS

IMRT Non- IMRT

p

Nutting 2011 (PARSPORT)

oropharynx hypopharynx

47/47

29% 74% 78%

83% 41% 76%

<0,001 0,002 NS

Kam 2007

nasopharynx

28/28

Xerostomia ≥2 (1y)

39% 82% 0,001

Evidence

Gupta 2012 Rathod 2013

oropharynx hypopharynx larynx

32/28

Acute xerostomia ≥2 Xerostomia ≥2 (2y) SC fibrosis (2y) 3y OS QOL

59% 23% 14% 71% better better better

89% 59% 56% 68%

0,003 0,02 0,005 NS <0,05 0,002 <0,001

Pow 2006

nasopharynx

46/50 Saliva flow QOL

(& comparative case studies)

28