PracticeUpdate: Cardiology

VOL. 1 • No. 3 • 2016 ISSN 2206-4672



AHA 2016’s superstars:

In GLAGOV, with the remarkable lipid lowering enabled by the combination of statin and anti- PCSK9 antibodies, we may be wringing as much “milk out of the stone” as we can by lessening lipid accumulation in the atheroma.

FUTURE, EUCLID, ART, PRECISION and GLAGOV Find out why they are practice-changers.


The findings not only add context

to knowledge of antiplatelet

monotherapy after revascularisation for peripheral artery disease, but they also highlight the need formore trials of antithrombotic agents after revascularisation. FUTUREmay cast some uncertainty on the future of the use of FFR in clinical practice. Further data are needed on the impact on decision making and how this 8 In the PRECISION post-hoc analyses of any CV, GI, or renal event, celecoxib had the lowest risk, naproxen had intermediate risk and ibuprofen the highest risk. These findings are striking as they grant absolution to a drug condemned in the cardiovascular community. 9 could be linked to adverse outcomes. 9

Special feature. 4–10

Association of systolic blood pressure variability with mortality, coronary heart disease, stroke, and renal disease Journal of the American College of Cardiology Results showed that the higher the variability (measured in standard deviation quartiles), the greater the association with all-cause mortality, CHD, stroke, and ERSD.

Coupling data mining and laboratory experiments to discover drug interactions causing QT prolongation Journal of the American College of Cardiology The use of data combined with laboratory experiments can identify QT-DDIs. There is a significantly increased risk of a prolonged QT interval in patients taking ceftriaxone and lansoprazole in combination.

Retinal vessel calibers in predicting long-term cardiovascular outcomes: the Atherosclerosis Risk in Communities Study Circulation This study validates the incremental benefit of retinal vessel caliber measurement for evaluating risk for ischemic stroke and death in the general population. It appears to be of particular value in predicting risk of coronary heart disease in women classified as low- risk by the 2013 PCE. 14

Life expectancy after myocardial infarction, according to hospital performance The New England Journal of Medicine Patients treated in high-performing hospitals following myocardial infarction have an extended life expectancy, consistent with a lower 30-day risk-standardized mortality rate, when compared with patients treated in low-performing hospitals.




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