CROI 2015 Program and Abstracts

Oral Sessions

Session TD-Q Themed Discussion

Room 6AB

302 Persistent Elevation of Inflammation Markers in HIV+ Persons With CMV Disease Melissa Schechter 1 ; Bruno Andrade 2 ; Eleanor M.Wilson 1 ;Virginia Sheikh 2 ; Sonya Krishnan 2 ; Margaret Caplan 1 ; Gregg Roby 2 ; Adam Rupert 3 ; Peter Burbelo 4 ; Irini Sereti 2 1 NIAID, Leidos Biomedical Inc., Fredrick, MD, US; 2 National Institute of Allergy and Infectious Diseases, Bethesda, MD, US; 3 NIAID, Leidos Biomedical Inc., Fredrick, MD, US; 4 National Institute of Dental and Craniofacial Research, Bethesda, MD, US 303 sCD163 Increase in HIV/CMV-Coinfected Subjects Included in ICONA Cohort Serena Vita 3 ; Miriam Lichtner 1 ; Giulia Marchetti 2 ; Claudia Mascia 3 ; Esther Merlini 2 ; Paola Cicconi 2 ;VincenzoVullo 3 ; Pier LuigiViale 5 ; Alberto Costantini 4 ; Antonella d’Arminio Monforte 2 On behalf of the Icona Foundation Study 1 University of Rome La Sapienza, Polo Pontino, Latina, Italy; 2 San Paolo Hospital, Milano, Italy; 3 University of Rome La Sapienza, Rome, Italy; 4 University of Ancona, Ancona, Italy; 5 University of Bologna, Bologna, Italy 304 Genital CMV Shedding Predicts Syphilis Acquisition in HIV-Infected MSM on ART Sara GianellaWeibel 1 ; David M. Smith 1 ; Eric Daar 2 ; Michael Dube 3 ; Andrea Lisco 4 ; ChristopheVanpouille 5 ; Richard Haubrich 1 ; Sheldon Morris 1 1 University of California San Diego, La Jolla, CA, US; 2 Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, Torrance, CA, US; 3 University of Southern California Keck School of Medicine, Los Angeles, CA, US; 4 National Institute of Allergy and Infectious Diseases, Bethesda, MD, US; 5 National Institute of Child Health and Human Development, Bethesda, MD, US 1:30 pm– 2:30 pm Leaky Latency Themed Discussion Leader Monique Nijhuis , University Medical Center Utrecht, Utrecht, Netherlands 392 Defective HIV-1 Proviruses Can Be Transcribed Upon Activation Session TD-F Themed Discussion Room 6D Ya-Chi Ho ; Ross Pollack; PatrickYong; Robert F. Siliciano Johns Hopkins University School of Medicine, Baltimore, MD, US 391 Influenza Vaccination Increases HIV-1 Transcription During Antiretroviral Therapy Christina C. Yek 1 ; Sara Gianella 1 ; Montserrat Plana 2 ; Pedro Castro 2 ; Felipe Garcia 2 ; Marta Massanella 1 ; David M. Smith 1 1 University of California San Diego, San Diego, CA, US; 2 University of Barcelona, Barcelona, Spain 427 Measurements of Viral Transcription in Elite Suppressor CD4+ T Cells Christopher W. Pohlmeyer ; C. Korin Bullen; Greg Laird; Alyssa R. Martin;VictoriaWalker- Sperling; Stanley U. Chioma; Robert F. Siliciano; Joel Blankson Johns Hopkins University School of Medicine, Baltimore, MD, US 384 Minor Contribution of Host-HIV Readthrough Transcripts to the Level of HIV-1 gag RNA Alexander Pasternak 1 ; Una O’Doherty 2 ; Ben Berkhout 1 1 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands; 2 University of Pennsylvania, Philadelphia, PA, US 379 Characterizing the Active HIV Reservoir on ART: Cell-Associated HIV RNA and Viremia Feiyu Hong ; Elizabeth Fyne; Anthony R. Cillo; Margaret A. Bedison; Dianna Koontz; John W. Mellors University of Pittsburgh, Pittsburgh, PA, US 390 Nascent LTR-Driven Transcription Can Lead to Translation of HIV Proteins in Resting CD4+ T Cells Laura DeMaster 1 ; Alexander Pasternak 2 ; Una O’Doherty 1 1 University of Pennsylvania, Philadelphia, PA, US; 2 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands

1:30 pm– 2:30 pm Fat Without Borders: Metabolic Complications in Resource- Limited Settings Themed Discussion Leader Miriam Rabkin , Columbia University Mailman School of Public Health, Chapel Hill, NC, US 778 Obesity and Inflammation in Resource-Diverse Settings of ART Initiation Kristine M. Erlandson 1 ; Nikhil Gupte 2 ; Javier R. Lama 3 ; Patcharaphan Sugandhavesa 4 ; Thando Mwelase 5 ; Ashwin Balagopal 2 ; David Asmuth 6 ;Thomas B. Campbell 1 ; Amita Gupta 2 On behalf of the A5175 and NWCS319 study team 1 University of Colorado, Aurora, CO, US; 2 Johns Hopkins University, Baltimore, MD, US; 3 Impacta Peru Clinical Trials Unit, Lima, Peru; 4 Chiang Mai University, Chiang Mai, Thailand; 5 University of Witswatersrand, Johannesburg, South Africa; 6 University of California Davis, Sacramento, CA, US 779 Body Composition Outcomes at 96Weeks in the SECOND-LINE RCT DXA Substudy Mark A. Boyd 1 ; Janaki Amin 1 ; PatrickW. Mallon 2 ; Jennifer F. Hoy 3 ; Samuel Ferret 4 ;Waldo Belloso 5 ; Praphan Phanuphak 6 ; Sean Emery 1 ; David A. Cooper 1 On behalf of the SECOND-LINE study group 1 University of New South Wales Australia, Sydney, Australia; 2 University College Dublin, Dublin, Ireland; 3 Monash University/Alfred Hospital, Melbourne, Australia; 4 Hopital Saint Louis, Paris, France; 5 Hospital Italiano, Buenos Aires, Argentina; 6 Thai Red Cross AIDS Research Centre, Bangkok, Thailand 780 Bone Quality by Quantitative Ultrasound at the Radius Does Not Differ in ART-Naïve HIV+ and HIV- RwandanWomen Eugene Mutimura 1 ; Qiuhu Shi 2 ; Donald R. Hoover 3 ; Kathryn Anastos 4 ; Emmanuel Rudakemwa 5 ; Jean Claude Dusingize 1 ; Jean D’Amour Sinayobye 1 ; MichaelTYin 6 1 Regional Alliance for Sustainable Development, Kigali, Rwanda; 2 School of Health Sciences and Practice, New York Medical College, New York, NY, US; 3 State University of New Jersey, New Brunswick, NJ, US; 4 Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, US; 5 King Faisal Hospital, Kigali, Rwanda; 6 Columbia University Medical Center, New York, NY, US 781 Predictors and Outcomes of Incident High Cholesterol in Adults on ART in South Africa Denise Evans 1 ; AlanaT. Brennan 2 ; Faith Moyo 1 ; David Spencer 3 ; Kay Mahomed 3 ; Mhairi Maskew 1 ; Lawrence Long 1 ; Sydney Rosen 2 ; Matt P. Fox 2 1 University of the Witwatersrand, Johannesburg, South Africa; 2 Boston University, Boston, MA, US; 3 Right to Care, Johannesburg, South Africa 782 Metabolic Changes and Second-Line ART in Africa (2LADY/ANRS 12169 Trial) Amandine Cournil 1 ; Assane Diouf 3 ; Sabrina Eymard-Duvernay 1 ; Adrien Sawadogo 2 ; Liliane Ayangma 4 ; Louise Fortes-Deguenonvo 3 ; Jean-Marc Mben 6 ; Eric Delaporte 1 ; Laura Ciaffi 1 ; Sinata Koulla-Shiro 5 1 IRD/UM 1, Montpellier, France; 2 CHU Souro Sanou, Bobo Dioulasso, Burkina Faso; 3 CRCF, Dakar, Senegal; 4 Yaounde Military Hospital, Yaounde, Cameroon; 5 FMSB/University Yaounde 1, Yaounde, Cameroon; 6 ANRS Research Center, Yaounde, Cameroon 1:30 pm– 2:30 pm Hormonal Contraceptives: Enduring Controversy Themed Discussion Leader Betsy Herold , Albert Einstein College of Medicine, Bronx, NY, US 859 Estrogen Replacement in Healthy Postmenopausal Women Reduces %CCR5+ CD4+ T Cells Amie Meditz 1 ; Samantha MaWhinney 2 ; Kerrie Moreau 2 ; Kelsey Melander 2 ; Joy Folkvord 2 ; Wendy Kohrt 2 ; MargaretWierman 2 ; Elizabeth Connick 2 1 Boulder Community Health, Boulder, CO, US; 2 University of Colorado Anschutz Medical Campus, Aurora, CO, US Session TD-S Themed Discussion Room 6C

Tuesday, February 24, 2015 • Oral Sessions

6

CROI 2015