CROI 2015 Program and Abstracts

Poster Listings

370 Vaccine Induced Follicular CD8 T Cells Enhance Control of Pathogenic SIV Infection Geetha H. Mylvaganam ; Daniel Rios; GregoryTharp; Steven Bosinger;VijayakumarVelu; Rama R. Amara Emory University, Atlanta, GA, US 371 Blockade of PD-L1 Does Not Reverse HIV Latency in CD4+ T Cells Ex Vivo Elizabeth Fyne 1 ; Shalyn Campellone 2 ; Huilin Qi 2 ; Amy Sheaffer 2 ; Stephen Mason 2 ; JohnW. Mellors 1 1 University of Pittsburgh, Pittsburgh, PA, US; 2 Bristol-Myers Squibb Co., Wallingford, CT, US 372 Impact of HIV Latency Reversing Agents on Natural Killer Cells Carolina Garrido ; Julia Sung; Swati Gupta; Katherine Sholtis; Nancie Archin; David Margolis Medicine, University of North Carolina University of North Carolina, Chapel Hill, NC, US 2:30 pm– 4:00 pm Viral Reservoir Dynamics During ART 373 The Earlier cART Is Initiated During PHI, the More Intracellular HIV-DNA Decreases Moussa Laanani 2 ; Jade Ghosn 1 ; Asma Essat 2 ; Adeline Mélard 3 ; Rémonie Seng 2 ; Emmanuel Mortier 4 ; Cécile Goujard 2 ; Laurence Meyer 2 ; Christine Rouzioux 3 On behalf of the ANRS PRIMO Cohort Study Group 1 APHP, Hôtel Dieu University Hospital, Paris, France; 2 APHP, Bicêtre Hospital, Le Kremlin-Bicêtre, France; 3 APHP, Necker Hospital, Paris, France; 4 APHP, Louis Mourier Hospital, Colombes, France 374 Decay Rate and HIV-1 DNA Reservoir Size Following Early Infant Antiretroviral Therapy Priyanka Uprety 1 ; Kaitlin Rainwater-Lovett 2 ; Ellen G. Chadwick 3 ; Edmund Capparelli 4 ; Carrie Ziemniak 2 ; Katherine Luzuriaga 5 ; Larry Moulton 1 ; Deborah Persaud 2 International Maternal Pediatric Adolescent AIDS ClinicalTrial Network (IMPAACT) P1030 trial group 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 2 Johns Hopkins University School of Medicine, Baltimore, MD, US; 3 Northwestern University, Feinberg School of Medicine, Chicago, IL, US; 4 University of California San Diego, San Diego, CA, US; 5 University of Massachusetts Medical School, Boston, MA, US 375 Detectable CMV in PBMC Is AssociatedWith Slower HIV DNA Decay During Suppressive ART Sara GianellaWeibel ; Christy Anderson; Susanna R.Var; Michelli Faria de Oliveira; Marta Massanella; Susan J. Little; Douglas D. Richman; Matt Strain; Josue Pérez-Santiago; David M. Smith University of California San Diego, La Jolla, CA, US 376 Stable Total HIV-1 DNA Levels Prior and Post ART Interruption in Chronic HIV Emmanouil Papasavvas 1 ; Matthew Strain 2 ; Steven Lada 2 ; Jocelin Joseph 1 ; Livio Azzoni 1 ; KaramMounzer 3 ; Jay R. Kostman 4 ; Douglas D. Richman 2 ; Luis J. Montaner 1 1 The Wistar Institute, Philadelphia, PA, US; 2 VA San Diego Healthcare System and the University of California, San Diego, CA, US; 3 Jonathan Lax Immune Disorders Treatment Center, Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, PA, US; 4 Presbyterian Hospital–University of Pennsylvania Hospital, Philadelphia, PA, US 377 Aviremia 10-Year Post-ART Discontinuation Initiated at Seroconversion Sabine I. Kinloch 1 ; Lucy Dorrell 2 ; HongbingYang 2 ; LinosVandekerckhove 3 ;Ward de Spiegelaere 3 ; Eva Malatinkova 3 ; SabineYerly 4 ; DanielWebster 5 ; Margaret Johnson 5 1 University College London, London, United Kingdom; 2 University of Oxford, Oxford, United Kingdom; 3 Universitair Ziehenhuis Gent, Gent, Belgium; 4 Geneva University Hospital, Geneva, Switzerland; 5 Royal Free London NHS Foundation Trust, London, United Kingdom 378 Identifying HIV Variants that Rebound after Treatment Interruption Mary F. Kearney 2 ;Wei Shao 3 ; RajeshT. Gandhi 4 ; Brandon F. Keele 3 ; Jonathan Z. Li 1 1 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US; 2 National Cancer Institute (NCI), Frederick, MD, US; 3 Frederick National Laboratories for Cancer Research, Frederick, MD, US; 4 Massachusetts General Hospital, Harvard Medical School, Boston, MA, US THURSDAY, FEBRUARY 26, 2015 Session P-F2 Poster Session Poster Hall

379 Characterizing the Active HIV Reservoir on ART: Cell-Associated HIV RNA and Viremia Feiyu Hong ; Elizabeth Fyne; Anthony R. Cillo; Margaret A. Bedison; Dianna Koontz; John W. Mellors University of Pittsburgh, Pittsburgh, PA, US 380 Liver Macrophages and HIV-1 Persistence Abraham J. Kandathil ; Christine M. Durand; Jeffrey Quinn; Andrew Cameron; David L. Thomas; Ashwin Balagopal Johns Hopkins School of Medicine, Baltimore, MD, US 381 Large-Scale Analysis of HIV-1 Integration Sites in Untreated and Treated Patients Stephanie Laufs 1 ; Diana Schenkwein 1 ; Neeltje Kootstra 2 ; Frank A. Giordano 5 ; Christoph Stephan 3 ; Hans-Georg Kraeusslich 4 ;Winfried Kern 6 ; Susanne Usadel 6 ; Manfred Schmidt 1 ; Christof von Kalle 1 1 National Center for Tumor Diseases; German Cancer Research Center, Heidelberg, Germany; 2 Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands; 3 University Hospital Frankfurt, Frankfurt, Germany; 4 Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany; 5 Heidelberg University, Heidelberg, Germany; 6 Division of Infectious Diseases, Department of Medicine, Albert- Ludwigs-University Center for Infectious Diseases & Travel Medicine, and IFB-Center for Chronic Immunodeficiency, University Hospital, Freiburg, Germany 382 Identical Sequence Expansions Are Predominantly Found in Effector Memory T Cells Susanne von Stockenstrom 1 ; Eunok Lee 2 ; Lina Odevall 1 ; Elizabeth Sinclair 3 ; Hiroyu Hatano 3 ; Peter Bacchetti 4 ; PeterW. Hunt 3 ; Steven G. Deeks 3 ; Frederick M. Hecht 3 ; Sarah E. Palmer 2 1 Karolinska Institutet, Stockholm, Sweden; 2 Westmead Millenium Institute and University of Sydney, Sydney, Australia; 3 Department of Medicine, University of California San Francisco, San Francisco, CA, US; 4 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, US 383 Long-Term Effect of Temporary ART During Primary HIV Infection on the Viral Reservoir Alexander Pasternak 1 ; Jan Prins 2 ; Ben Berkhout 1 1 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands; 2 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands Session P-F3 Poster Session Poster Hall 2:30 pm– 4:00 pm Cellular Factors of Latency 384 Minor Contribution of Host-HIV Readthrough Transcripts to the Level of HIV-1 gag RNA Alexander Pasternak 1 ; Una O’Doherty 2 ; Ben Berkhout 1 1 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands; 2 University of Pennsylvania, Philadelphia, PA, US 385 MicroRNA-155 Reinforces HIV Latency by Downregulating the TRIM32 Viral Activator Debbie S. Ruelas 2 ; Jonathan Chan 2 ; Eugene Oh 1 ; Amy Heidersbach 2 ; Andrew Hebbeler 2 ; Leonard Chavez 2 ; EricVerdin 2 ;Warner C. Greene 2 1 University of California San Francisco (UCSF), San Francisco, CA, US; 2 University of California Berkeley, Berkeley, CA, US 386 Select Host Restriction Factors Are AssociatedWith HIV Persistence During Therapy Mohamed Abdel-Mohsen 1 ; Leonard Chavez 1 ; CharleneWang 1 ; Matt Strain 2 ; Xutao Deng 1 ; Christopher D. Pilcher 3 ;Teri Liegler 3 ; Douglas D. Richman 2 ; Steven Deeks 3 ; Satish Pillai 1 1 Blood Systems Research Institute, San Francisco, CA, US; 2 University of California San Diego, La Jolla, CA, US; 3 University of California San Francisco, San Francisco, CA, US 387 Selectively Eliminating HIV Latently Infected Cells Without Viral Reactivation Grant R. Campbell ; Rachel S. Bruckman;Yen-Lin Chu; Stephen A. Spector University of California San Diego, La Jolla, CA, US

Poster Listings

35

CROI 2015