CROI 2015 Program and Abstracts

Poster Listings

426 HIV-1 Reprograms Resting CD4 T Cells via Foxo1 and L-Selectin Suppression BenjaminTrinité 1 ; Chi N. Chan 1 ; Caroline S. Lee 1 ; Joy Folkvord 2 ; Elizabeth Connick 2 ; David N Levy 1 1 New York University, New York, NY, US; 2 University of Colorado Anschutz Medical Campus, Aurora, CO, US 427 Measurements of Viral Transcription in Elite Suppressor CD4+ T Cells Christopher W. Pohlmeyer ; C. Korin Bullen; Greg Laird; Alyssa R. Martin;VictoriaWalker- Sperling; Stanley U. Chioma; Robert F. Siliciano; Joel Blankson Johns Hopkins University School of Medicine, Baltimore, MD, US 428LB Short-Term Disulfiram to Reverse Latent HIV Infection: A Dose Escalation Study Julian H. Elliott 1 ; James H. McMahon 1 ;Wendy Hartogensis 2 ; Namandje Bumpus 3 ; Christina Chang 4 ; Sulggi A. Lee 2 ; Jeff Lifson 5 ; Peter Bacchetti 2 ; Steven Deeks 2 ; Sharon R. Lewin 4 on behalf of the Disulfiram Study investigators 1 Monash University/Alfred Hospital, Melbourne, Australia; 2 University of California San Francisco, San Francisco, CA, US; 3 Johns Hopkins University, Baltimore, MD, US; 4 University of Melbourne, Melbourne, Australia; 5 National Cancer Institute, Frederick, MD, US 2:30 pm– 4:00 pm Stem Cell Transplantation 429 Impact of Combination of Chemotherapy and Autologous Hematopoietic Stem-Cell Transplantation for Lymphoma on HIV Reservoir Persistence Heloise Delagreverie ; laurence Gerard; Marie Laure Chaix; Marie Laure Nere; Lionel Galicier; Francois Simon; Eric Oksendenhendler; Constance Delaugerre Hôpital Saint-Louis, APHP, Université Paris Diderot, Paris, France 430 HIV-1 Reservoirs and Humoral Immunity in Allogeneic Stem Cell Transplantation Patients Kathryn E. Stephenson 1 ; George H. Neubauer 1 ; Emily Hanhauser 2 ; Marcelo J.Wolff 3 ; Cristian Carvallo 3 ; Francisco M. Marty 4 ; Steven G. Deeks 5 ; Daniel R. Kuritzkes 6 ; Dan H. Barouch 1 ;Timothy J. Henrich 6 1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US; 2 Brigham and Women’s Hospital, Boston, MA, US; 3 Clinica Santa Maria, Santiago, Chile; 4 Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US; 5 University of California San Francisco (UCSF), San Francisco, CA, US; 6 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US 431 Breakthrough of Preexisting X4-Capable HIV After Allogeneic Stem-Cell Transplantation Jens Verheyen 1 ; AlexanderThielen 2 ; Miriam Dirks 1 ; Nadine Lübke 3 ; MarekWidera 1 ; Lambros Kordelas 1 ; Martin Däumer 2 ; Rolf Kaiser 3 ; Stefan Esser 1 1 University Hospital Essen, University Duisburg-Essen, Essen, Germany; 2 Institute of Immunology and Genetics, Kaiserslautern, Germany; 3 University of Cologne, Cologne, Germany; 4 University Hospital Essen, University Duisburg-Essen, Essen, Germany; 5 University Hospital Essen, University Duisburg-Essen, Essen, Germany Rafael Duarte 1 ; Maria Salgado 2 ; Isabel Sanchez-Ortega 1 ; Sara Morón-López 2 ; Maria C. Puertas 2 ; Lawrenze D. Petz 4 ; Sergi Querol 3 ; Bonaventura Clotet 2 ; Javier Martínez-Picado 2 1 Institut Català d’Oncologia, L’Hospitalet del Llobregat, Spain; 2 IrsiCaixa Institute for AIDS Research, Badalona, Spain; 3 Barcelona Cord Blood Bank, Barcelona, Spain; 4 StemCyte International Cord Blood Center, Covina, CA, US 433 CCR5 Editing in Hematopoietic Stem Cells in a Nonhuman Primate Model of HIV/AIDS Christopher W. Peterson 1 ; JianbinWang 2 ; Patricia Polacino 3 ; Michael C. Holmes 2 ; Shiu-Lok Hu 3 ; Philip D. Gregory 2 ; Hans-Peter Kiem 1 1 Fred Hutchinson Cancer Research Center, Seattle, WA, US; 2 Sangamo BioSciences, Inc., Richmond, CA, US; 3 University of Washington, Seattle, WA, US 432 Allogeneic TransplantationWith CCR5 Δ 32/ Δ 32 Cord Blood Hematopoietic Cells in an HIV-1-Infected Patient Session P-F9 Poster Session Poster Hall

434 Cytoxan Enhancement of SB-728-T Engraftment: A Strategy to Improve Anti-HIV Response Gary Blick 2 ; Jay Lalezari 3 ; Ricky Hsu 4 ; Erin DeJesus 5 ;Trevor Hawkins 6 ; RonaldT. Mitsuyasu 7 ; ShelleyWang 1 ; Gary Lee 1 ; Winson Tang 1 ; Dale Ando 1 1 Sangamo BioSciences, Inc., Richmond, CA, US; 2 CIRCLE CARE Center, Norwalk, CT, US; 3 Quest Clinical Research, San Francisco, CA, US; 4 New York University School of Medicine, New York, NY, US; 5 Orlando Immunology Center, Orlando, FL, US; 6 Southwest Care Center, Santa Fe, NM, US; 7 University of California Los Angeles CARE Center, Los Angeles, CA, US

TUESDAY, FEBRUARY 24, 2015 Session P-G1 Poster Session

Poster Hall

2:30 pm– 4:00 pm CNS Reservoirs 435 Highly Precise Measurements of HIV DNA in CSF and Blood by Droplet Digital PCR Michelli Faria de Oliveira 1 ; Sara Gianella 1 ; Scott Letendre 2 ; Konrad Scheffler 1 ; Sergei L. Kosakovsky Pond 1 ; Davey M. Smith 1 ; Matt Strain 1 ; Ronald J. Ellis 2 1 University of California San Diego, La Jolla, CA, US; 2 HIV Neurobehavioral Research Center, San Diego, CA, US 436 Antiretroviral Concentrations in Brain Tissue Are Similar to or Exceed Those in CSF. Namandjé Bumpus 2 ; Qing Ma 4 ; David J. Moore 1 ; Brookie M. Best 1 ; Ronald J. Ellis 1 ; Cristian L. Achim 1 ; Melanie Crescini 1 ; Courtney Fletcher 3 ; Igor Grant 1 ; Scott Letendre 1 The CNTN Group 1 University of California San Diego, San Diego, CA, US; 2 Johns Hopkins University School of Medicine, Baltimore, MD, US; 3 University of Nebraska Medical Center, Omaha, NE, US; 4 University at Buffalo, Buffalo, NY, US 437 HIV DNA Peripheral Reservoirs Have a Nonlinear Impact on Brain Pathology William Hey-Cunningham 2 ; Nadene Dermody 3 ; Phillip Chan 4 ; Bruce Brew 5 ; Kersten Koelsch 2 ; Lucette A. Cysique 1 1 NeuRA, University of New South Wales, Randwick, Australia; 2 Kirby Institute, University of New South Wales, Sydney, Australia; 3 Macquarie University, Sydney, Australia; 4 Queen Elizabeth Hospital, HKSAR, Hong Kong, China; 5 St. Vincent’s Hospital, University of New South Wales, Sydney, Australia 438 Acute HIV CSF/Plasma RNA Ratios Are Variable and Greater Than in Chronic HIV Joanna Hellmuth 1 ; Serena Spudich 2 ; Eugene Kroon 3 ; Naponpon Sailasuta 4 ; Somprartthana Rattanamanee 3 ; Sukalaya Lerdlum 5 ; Linda L. Jagodzinski 6 ; Shelly J. Krebs 7 ; Jintanat 1 University of California San Francisco, San Francisco, CA, US; 2 Yale University School of Medicine, New Haven, CT, US; 3 Thai Red Cross AIDS Research Centre, Bangkok, Thailand; 4 University of Hawaii, Honolulu, HI, US; 5 Chulalongkorn University, Bangkok, Thailand; 6 Walter Reed Army Institute of Research, Silver Spring, MD, US; 7 Henry M. Jackson Foundation for the Advancement of Military Medicine, Silver Spring, MD, US; 8 US Military HIV Research Program, Bethesda, MD, US 439 Greater CSF HIV Reduction and CSF Rapid Decay Associated with Improved Neurocognition Kevin R. Robertson 1 ; Natalie M. Bowman 1 ; Sarah B. Joseph 1 ; Prema Menezes 1 ; Nisha Bhatia 2 ; Christopher Lippincott 1 ; MichaelVinikoor 1 ; Joseph Eron 1 ; Ronald Swanstrom 1 ; Richard Price 2 THINC UNC 1 University of North Carolina, Chapel Hill, Chapel Hill, NC, US; 2 University of California San Francisco, San Francisco, CA, US 440 HIV-1 Replication in the CNS Is AssociatedWith Increased Neurocognitive Impairment Sarah B. Joseph 1 ; Laura Kincer 1 ; Natalie M. Bowman 1 ; Prema Menezes 1 ; Kevin Robertson 1 ; Albert M. Anderson 2 ; DavidW. Loring 3 ; Joseph J. Eron 1 ; RichardW. Price 4 ; Ronald Swanstrom 1 1 University of North Carolina, Chapel Hill, Chapel Hill, NC, US; 2 Emory University, Atlanta, GA, US; 3 Emory University, Atlanta, GA, US; 4 University of California San Francisco, San Francisco, CA, US; 5 University of North Carolina, Chapel Hill, Chapel Hill,, NC, US Ananworanich 8 ; Victor G. Valcour 1 The RV254/SEARCH010 Study Group

Poster Listings

38

CROI 2015