CROI 2015 Program and Abstracts

Poster Listings

806 APRI and FIB4: AssociatedWith D-Drug Exposure, Low CD4 Count and Monocyte Activation KatherineW. Kooij 1 ; Rosan van Zoest 1 ; FerdinandW.Wit 1 ; Judith Schouten 2 ; Neeltje Kootstra 2 ; Ineke G. Stolte 3 ; Maria Prins 3 ; Peter Reiss 1 ; Marc van derValk 2 AGEhIV Cohort Study Group 1 Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands; 2 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands; 3 Public Health Service of Amsterdam, Amsterdam, Netherlands 807 HIV and Liver Fibrosis Among Prison Inmates: The IeDEAWest Africa Collaboration Antoine Jaquet 1 ; GillesWandeler 2 ; JudicaelTine 3 ; Claver Dagnra 4 ; Alain Attia 5 ; Akouda Patassi 6 ; Abdoulaye Ndiaye 7 ; Koumavi K. Ekouevi 8 ; Moussa Seydi 3 ; François Dabis 1 1 Inserm U897, ISPED, Université de Bordeaux, Bordeaux, France; 2 Department of Infectious Diseases, Bern University Hospital, Bern, Switzerland; 3 Service de Maladies Infectieuses et Tropicales, CRCF, CHU de Fann, Dakar, Senegal; 4 Service de Virologie, BIOLIM, Université de Lomé, Lomé, Togo; 5 Service de Hépato-Gastroentérologie, CHU de Yopougon, Abidjan, Côte d’Ivoire; 6 Service de Maladies Infectieuses et Tropicales, CHU Sylvanus Olympio, Lomé, Togo; 7 Service de Médecine Interne, CHU Aristide Le Dantec, Dakar, Senegal; 8 Département de Santé Publique, Faculté des Sciences de la Santé, Université de Lomé, Lomé, Togo 2:30 pm– 4:00 pm Depression and Alcohol Use Disorders 808 Clinical Correlates of Alcohol Use Disorders Among HIV-Infected Adults in Zambia Michael J. Vinikoor 1 ; Masumba Masaninga 2 ; Carolyn Bolton Moore 3 ;Virginia Munamunungu 4 ; Alice Siyunda 4 ; Lloyd Mulenga 5 ; Matthias Egger 6 ; Benjamin H. Chi 3 ; Gilles Wandeler 6 IeDEA Southern Africa 1 University of North Carolina, Lusaka, Zambia; 2 Lusaka District Health Management Team, Lusaka, Zambia; 3 University of North Carolina, Chapel Hill, NC, US; 4 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; 5 University of Zambia, Lusaka, Zambia; 6 Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland 809 Depression and Treatment Outcomes Among Tanzanian Adults Initiating HAART Christopher R. Sudfeld 1 ; Sylvia Kaaya 2 ; Nilupa S. Gunaratna 1 ;Wafaie Fawzi 1 ; Ferdinand Mugusi 2 ; Mary C. Smith Fawzi 3 1 Harvard School of Public Health, Roxbury Crossing, MA, US; 2 Muhimbili University of Health and Allied Sciences, Dar es Salaam, United Republic of Tanzania; 3 Harvard Medical School, Boston, MA, US Session P-Q13 Poster Session Poster Hall 2:30 pm– 4:00 pm Immune Reconstitution Inflammatory Syndrome in Opportunistic Infections 810 Discordant Early Immune Responses Distinguish TB IRIS and Death in HIV/TB Coinfection Shruthi Ravimohan 1 ; NeoTamuhla 2 ; Andrew Steenhoff 2 ; Rona Letlhogile 2 ; Kebatshabile 811 WITHDRAWN 812 Exuberant Pathogen-Specific Th1 CD4+ T-Cell Responses in MAC-IRIS in HIV Infection Kimberly F. Faldetta 1 ; Denise C. Hsu 1 ;Virginia Sheikh 1 ; Gregg Roby 2 ; Kenneth Olivier 1 ; Irini Sereti 1 1 National Institutes of Health (NIH), Rockville, MD, US; 2 National Institutes of Health (NIH), Bethesda, MD, US Nfanyana 2 ;Tumelo Rantleru 2 ; Robert Gross 1 ; DrewWeissman 1 ; Gregory P. Bisson 1 1 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, US; 2 Botswana University of Pennsylvania Partnership, Gaborone, Botswana TUESDAY, FEBRUARY 24, 2015 Session P-R1 Poster Session Poster Hall

813 A Paradoxical Treatment of Mycobacterial Immune Reconstitution Inflammatory Syndrome Denise C. Hsu; Kimberly F. Faldetta; Luxin Pei ; DelmyraTurpin;Virginia Sheikh; Irini Sereti National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US 814 CD8 T Cells in Lesions of PML-IRIS Express CCR5: Rationale for the Use of Maraviroc Guillaume Martin-Blondel 2 ; Jan Bauer 1 ; Emmanuelle Uro-Coste 2 ; Hervé Dumas 2 ; Hans Lassmann 1 ; David Brassat 2 ; Pierre Delobel; Roland Liblau 3 ; Bruno Marchou 2 1 University of Vienna, Vienna, Austria; 2 Toulouse University Hospital, Toulouse, France; 3 Inserm, Toulouse, France 815 Monocyte Immune Responses in Cryptococcal Immune Reconstitution Inflammatory Syndrome David B. Meya 1 ; Godfrey Zziwa 2 ; Samuel Okurut 2 ; Stephen Cose 3 ; Paul Bohjanen 4 ; Sharon Wahl 5 ; David R. Boulware 4 ;Yuka Manabe 6 ; Edward N. Janoff 7 1 Makerere University College of Health Sciences, Kampala, Uganda; 2 Makerere University Walter Reed Project, Kampala, Uganda; 3 Medical Research Council, Kampala, Uganda; 4 University of Minnesota, Minneapolis, MN, US; 5 National Institute for Dental and Craniofacial Research, Bethesda, MD, US; 6 Johns Hopkins University School of Medicine, Baltimore, MD, US; 7 University of Colorado, Denver, CO, US 816LB Does HIV Infection Reduce the Probability of Transmission of Pulmonary Tuberculosis? Judith R. Glynn 1 ; José Afonso Guerra-Assunção 1 ; Rein M. Houben 1 ;Themba Mzembe 2 ; Lifted Sichali 2 ; PalwashaY. Khan 1 ; Ruth McNerney 1 ; Julian Parkhill 3 ;Taane G. Clark 1 ; Amelia C. Crampin 1 2:30 pm– 4:00 pm T-Cell Responses to Tuberculosis Infection 817 The Relationship Between T-Regulatory Cells and Latent Tuberculosis Infection in Household Contacts Exposed to Pulmonary Tuberculosis Infection in Kampala, Uganda Rhoda Namakula 1 ; Irene A. Odanga 2 ; Josephine Kasolo 2 ; Ekii A. Abuku 3 1 Makerere University–Johns Hopkins Research Collaboration, Kampala, Uganda; 2 Makerere University College of Health Sciences, Kampala, Uganda; 3 Medical Research Council (Uganda Virus Research Institute), Entebbe, Uganda 818 Antiretroviral Therapy Fails to Restore Mycobacterium Tuberculosis- specific Th1 and Th17 CD4 Responses LyleW. Murray 1 ; Dominique Goedhals 2 ; Iman Satti 1 ; Rodney Phillips 1 ; Helen McShane 1 ; John Frater 1 Phillips/Frater 1 University of Oxford, Oxford, United Kingdom; 2 University of the Free State, Bloemfontein, South Africa 819 Treg/Th17 and T-Cell Effector Responses in Tuberculosis Patients Coinfected with HIV Christine Lacabaratz 1 ; AurelieWiedemann 1 ; Celine Manier 1 ; Laure Bourdery 1 ; Mathieu Surenaud 1 ; Jean-Daniel Lelièvre 2 ; Giovanna Melica 3 ;Yves Lévy 2 1 INSERM U955, Université Paris-Est Créteil, Vaccine Research Institute, Créteil, France; 2 INSERM U955, Université Paris-Est Créteil, Vaccine Research Institute, CHU H. Mondor-A.Chenevier, Créteil, France; 3 CHU H. Mondor-A.Chenevier, Créteil, France 820 HIV-Tuberculosis Coinfection Leads to Increased Turnover of Late- Senescent CD8 + T Cells Shankar Esaki Muthu 1 ; ChongYee Kien 1 ; Alireza Saeidi 1 ; Adeeba Kamarulzaman 1 ; VijayakumarVelu 2 ; Marie Larsson 3 1 University of Malaya, Kuala Lumpur, Malaysia; 2 Emory University, Atlanta, GA, US; 3 Linkoping University, Linkoping, Sweden 821 CD8 T-Cell Terminal Differentiation and Its Regulation by DHEA in HIV-TB Coinfection Guadalupe V. Suarez 1 ; MatiasT. Angerami 1 ; Maria B.Vecchione 1 ; Omar Sued 2 ; Horacio Salomon 1 ; Maria F. Quiroga 1 1 INBIRS (UBA-CONICET), Buenos Aires, Argentina; 2 Fundacion Huesped, Buenos Aires, Argentina 1 London School of Hygiene and Tropical Medicine, London, United Kingdom; 2 Karonga Prevention Study, Chilumba, Malawi; 3 Wellcome Trust Sanger Institute, Hinxton, United Kingdom Session P-R2 Poster Session Poster Hall

Poster Listings

63

CROI 2015