Lower GI 2017

Contributing factors

Therapy’s related RT: Dose/volume, technique Concomitant CT (5FU, capecitabine) Surgery

Patient’s related Age, Sex (F>M)

Previous surgery Comorbidities (diabetes, hypertension, vascular disease…) Pelvic inflammatory disease

TOXICITY

Genetic susceptibility Behaviour: smoking

Tumor’s related Tissue distortion, Proteolitic enzymes, Cytokins

Stone HB et al. The Lancet Oncology 2003