AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)
Background information
Composition of human milk
Complex mixture of oligosaccharides
•
Lactose (68g/L)
Protein(10g/L)
• >200 HMO detected and ~160 HMO identified • Quantitative data available for ~30 HMO • Limited number of HMOs available in large scale 2’FL; 3FL; DFL
Fat(39 g/L)
O S (13 g/L)
LN n T; LNT 3’SL; 6’SL
• Commercially available Infant formula (IF) fortified with: 2’-FL & LN n T • No certified reference materials of IF/ADN are available
Background information Why quantifying HMO in Infant Formula? • R & D and product development • Confirmation of HMO level for safety trials, stability testing, efficacy trials, regulatory purposes • Quality control purposes to assure labeling compliance
Are there methods available? • Methods developed for (academic) HMO analysis in milk could be applied
• Small number of methods involving IF reported in literature • Methods not aligned as no official method is available
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