AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)

Vitamin A SMPR

Standard Method Performance Requirements (SMPR) AOAC SMPR 2011.003 Standard Method Performance Requirements for Vitamin A in Infant Formula and Adult/Pediatric Nutritional Formula a

7.0– 382.6*

• Analytical Range • Limit of Detection • Limit of Quantitation • Repeatability • Recovery • Reproducibility

Analytical Range

/100 g

*

Limit of Detection Limit of Quantitation Repeatability (RSDr)

7*

<8%

10* 100* 300*

mean spiked recovery

Recovery

90-110%

Reference Material - NIST 1849 is no longer available Replacement would be NIST 1869

Reproducibility (RSDR)

10*

<22% <16%

100*

200* 300* 383* a Concentrations apply to (1) “ready-to-feed” liquids “as is”; (2) reconstituted powders (25 g into 200 mL water); and (3) liquid concentrates diluted 1:1 by weight * /100 g expressed as 13-cis retinol and all-trans retinol in reconstituted final product.

Vitamin A Approved Methods