AOAC SPIFAN Stakeholder Panel Meeting Book (March 12, 2020)
Summary of Existing Methods for Nutrient in OMA, Chapter 50
AOAC
Technology Scope
Meets SMPR?
Remarks
986.23 Microbiological assay
All active forms of cobalamin (some inactive forms as well) Vitamin B12 (as cyanocobalamin) Vitamin B12 vitamers as cyanocobalamin
No
CCNFSDU41 has confirmed use of microbiological methods.
•
• Part of recommended methods (CX234) as Type III method
2011.08 LC-UV
Yes/No
Codex Type II method
•
• Several matrixes show SDR higher than SMPR
2011.09 LC-UV
Yes
Equivalent to 2014.02.
•
• Compares well to current Codex Type II • No full validation data on SPIFAN matrixes available
2014.02 LC-UV
Vitamin B12 (all active forms) as cyanocobalamin
Yes
Equivalent to 2011.09
•
• Compares well to current Codex Type II • Full validation on SPIFAN matrixes (including MLT data) available • Widely used
Conclusions
AOAC
Technology Scope
Meets SMPR?
Remarks
986.23 Microbiological assay
All active forms of cobalamin (some inactive forms as well) Vitamin B12 (as cyanocobalamin) Vitamin B12 vitamers as cyanocobalamin Vitamin B12 (all active forms) as cyanocobalamin
No
CCNFSDU41 has confirmed use of microbiological methods.
•
• Part of recommended methods (CX234) as Type III method • To be kept, although several drawbacks
2011.08 LC-UV
Yes
Codex Type II method
•
2011.09 LC-UV
Yes
Recommend to repeal
•
2014.02 LC-UV
Yes
Could be recommended as Type III
•
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